Stable isotope tracer

With the more and more extensive and in-depth application of peptides in the field of biomedicine, the demand for labeled and modified peptides is increasing, and the demand for quality is also increasing. Stable isotope labeling (isotope tracer method) is a typical one. Stable isotopically labeled peptides are peptides synthesized from stable isotopically labeled amino acids. In contrast to standard amino acids, isotope labeling refers to replacing the original 12C and 14N atoms with 2H, 13C, or 15N. Relabeled amino acids are non-radioactive, but have a larger molecular weight than standard amino acids. This difference in molecular weight can make it a powerful tool in protein quantitative analysis and protein structure analysis and MS (or NMR) identification. It can realize the study of peptide metabolism pathway, and can track the position and quantity movement changes of peptides containing stable isotopes in vivo or in vitro at any time. Its characteristics such as high sensitivity, simple positioning and accurate quantitization make isotope modification more and more widely concerned in the fields of medicine and biochemistry. The following are commonly isotopically labeled amino acids.