Stable Isotope Labeling
Proteomics, the study of proteins encoded by the genome, includes identification of post-translational modifications, structural analyses, protein localization studies, and protein quantitation. Mass spectroscopy-based techniques have evolved as a powerful tool in proteomics.Stable isotope labeled peptides (SIL peptides) are chemically and physically indistinguishable from their endogenous counterparts with respect to retention time, ionization efficiency, and fragmentation pathways. Peptides can be labeled with one or more isotopes of hydrogen, carbon, nitrogen, or oxygen by incorporating amino acids containing the desired isotopes such as 13C, 15N into the peptide during synthesis.
Application advantages of isotopes
· Quality—synthesized using pure materials and packaged using ArgonGuard
· Accuracy—concentration precision for reproducible results
· Sensitivity—provides for the absolute quantification of low-abundance proteins
· Specificity—Up to 100% peptide sequence specificity
· Flexibility—extensive list of available modifications, solvents, concentrations, and formats
We offer a wide range of labels
